Associate Provost for Research Boston University Medical Campus
NINDS - National Institute of Neurological Disorders and Stroke	Research Resources

Abstract

Abstract: DESCRIPTION (provided by applicant): The aim of this research proposal is to explore memory systems in HIV. In the last decade, important advances have been made in the domain of HIV and cognition, and research has focused mainly on injury to the basal ganglia and associated fronto-striatal systems. However, little is understood about the effects of the virus on other brain systems, especially those that when disrupted, often result in dementia. The proposed study has two specific aims. First, functional MRI will be employed to examine the functional integrity of hippocampal-prefrontal networks in the illness. Second, volumetric analysis of the hippocampus will be conducted using structural MRI methodology. This proposed multi-dimensional study represents the first formal investigation of hippocampal-prefrontal networks in HIV, and will therefore extend clinical understanding of the structural and functional changes that occur in the context of HIV infection.

Thesaurus Terms:

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Institution:	BOSTON UNIVERSITY
	881 COMMONWEALTH AVENUE
	BOSTON, MA 02215
Fiscal Year:	2006
Department:	PSYCHOLOGY
Project Start:	18-APR-2006
Project End:	17-APR-2008
ICD:	NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
IRG:	ZRG1